If you have a two-armed configuration with SSL offloading, you may need to enable subnet originating requests. This can either be done on a per-Virtual Service basis (Subnet Originating Requests field in Standard Options in the Virtual Service modify screen), or on a global basis (System Configuration > Miscellaneous Options > Network Options > Subnet Originating Requests).

Note: It is recommended that the Subnet Originating Requests option is enabled on a per-Virtual Service basis. While a one-armed configuration is not common, it is supported. For security best practice, you should separate the network that clients will connect to from the network that the Real Servers are on.